Wednesday, January 11, 2023

What are the 9 Secrets of Cannabis Medicine?


How is it possible that one single plant can cure almost 700 medical conditions including alzheimer's, cancer and corona? 

One of the biggest differences between Cannabis medicine and pharmaceutical drugs is that the pharmaceuticals generally have high potency only at one specific target, meaning a specific receptor which they are engineered to target. Cannabis targets all of our receptors, and this is why this medicine works so fast and so effectively for such a wide range of health issues. Cannabis is known to be effective in the treatment of 678 medical conditions. 

You can follow this link to look at the list. https://encod.org/it/notizie/2012/700-medicinal-uses-of-cannabis-sorted-by-disease/

This is also why Cannabis works so well with pharmaceutical drugs. And this has been a blessing over the years as many doctors have not even been aware that their patients were self-medicating with Cannabis as part of their treatment. This also proves that there are hardly any negative interactions between Cannabis and conventional medications, at low doses, but please always make sure that Cannabis is compatible with your doctors’ medicines because there are some exceptions as mentioned in my book Cannabis is The Human Companion Plant.

In my practice every patient's pharmaceuticals and supplements are checked for interactions with medical and recreational Cannabis. 

At the heart of disease prevention is the way in which we manage our response to stress


It’s important to be aware that not all stress is bad. In my opinion good stress is the stress that we put onto ourselves, for example running your own businesses and setting targets to do so…this is good stress. 

The bad stress is the type of stress that the government and corporations give away for free each and every day. So-called 'inflation', illegal taxes not to mention daylight robbery, all of this has caused humankind a decent amount of stress for several generations already and continues to do so. 

A human beings we were never designed to cope with the levels of stress that we are subjected to in this day and age.

First of all, stress affects us on a hormonal level and this leads to the actual blocking of our receptor system including the Endocannabinoid system (ECS) that is the master control system of all of our physiological systems within the human body. Stress is therefore considered a major endocrine disruptor in human beings.

Not only does stress block our receptors but it also inhibits receptor expression, making any level of healing almost impossible to achieve when the body is a state of stress. When receptor expression is inhibited this is what leads to the progression of cancer growth in the human body. Stress also inhibits the cancer fighting functions of anti-angiogenesis, apoptosis and autophagy in the human body. [1]

In Hong et al, published in the Journal Frontiers in Oncology, the scientists note in their abstract that:

“Repeated chronic stress increases the risk of a variety of diseases, such as cardiovascular disease, depression, endocrine disease, inflammation and cancer. A growing body of research has shown that there is a link between chronic stress and tumor occurrence in both animal studies and clinical studies. Chronic stress activates the neuroendocrine system (hypothalamic-pituitary-adrenal axis) and sympathetic nervous system. Stress hormones promote the occurrence and development of tumors through various mechanisms. In addition, chronic stress also affects the immune function of the body, leading to the decline of immune-monitoring ability and promote the occurrence of tumors. The mechanisms of chronic stress leading to tumor include inflammation, autophagy and epi-genetics. These factors increase the proliferation and invasion capacity of tumor cells and alter the tumor microenvironment.”

Stress also negatively impacts anti-angiogenesis treatment in the fight against cancer

Anti-angiogenesis treatment blocks the formation of blood vessels that give tumors their life. When the human is under chronic stress these types of medications no longer work as effectively and this leads to the spread of cancers. 

Stress not only causes many different types of cancer but it is also the number one catalyst to the increase in mental health conditions that we are witnessing at this time because stress makes everything worse for human beings. [2] 

But possibly of greater concern is the way in which stress eats away at our vitamin B resources and this leads to all kinds of problems involving insufficient blood oxygen due to insufficient production of red blood cells that carry oxygen in our blood. This is how conditions like neuropathy, brain hypoxia, brain fog and chronic fatigue syndrome manifest.

It is a lifestyle disorder brought about by intentionally created stress, negativity and the consumption of harmful and neuro-toxic chemical substances found everywhere on earth, in our environment, our food, water, soil, medications, everywhere, no one can escape these toxic substances not even at the North Pole. These are poisons that we all have to endure. 

All cause brain damage in one or another form, and this is why we are seeing such an increase in people suffering from neurological conditions. [3]

Fortunately in Cannabis we have a plant companion that can offer us the means to inspire and motivate ourselves, so we may properly re-build our self-esteem and learn to love ourselves again, and in so doing, end this ongoing depression and insecurity of the human condition. When it comes to mental health, no matter the origin, the important thing is that we can prove that Cannabis does offer anti-psychotic, neuro-genetic, anti-inflammatory and anti-spasmodic healing properties. [4]

In my 40 years of working with this plant I have identified 9 ancient ‘secrets’ that contribute towards and explain the miraculous healing properties of Cannabis medicine that I will love to share with you in this paper. 

There is a profound connection between plants and humans, and we must realize and recognize that as human beings we have practically evolved with Cannabis since the beginning of time. 

The Human Companion Plant can enhance life and help to deliver people from disease, pain and suffering, as it has been doing for thousands of years already. 

Far too many people have died unnecessarily because of lack of access to Cannabis. If only we had listened earlier; so many more lives could have been saved.


SECRET NO 1 ~ THC IS ONLY FOUND WITHIN THE CANNABIS PLANT

There are two major reasons why human beings need Cannabis, and why Cannabis is a real medicine.

First, is that all human beings have a biological system of receptors known as the ECS inside our bodies that requires the active cannabinoid known as THC (Tetrahydrocannabinol Delta 9 THC) to activate and modulate the Endocannabinoid System. 

THC is only found in the Cannabis plant unlike the many other plant cannabinoids that are found in a variety of plants in the world. 

Second, is, that all human beings produce a chemical known as Anandamide that is the scientifically known as the human version of THC because they are so similar.

There is very little THC or CBD in the raw plant material

It doesn’t matter how potent a Cannabis strain may be, the truth is there is only trace elements of CBD and THC in the raw plant. You can test this by chewing on some raw leaves and buds and you probably won’t feel anything. On the other hand some people are so sensitive that they could experience a “high” from cannabinoid-acids.

All cannabinoids found in Cannabis originate from the ‘mother-cannabinoid’ known as CBGA. As plants mature unique enzymes convert CBGA into the 3 main cannabinoid-precursors namely CBDA, THCA and CBCA. 

When THCA is converted by the decarboxylation process (heat and light) THC is found abundantly in female plant material with the highest concentration in the trichomes of the flowers. THC is also found in male Cannabis plants although in much lower concentrations. However, plants grown in the hot African sun can test higher for CBD and THC content because the sun has had time to directly heat plants. In this way natural sunlight does encourage CBD and THC production within the plant.

If you have ever spent a day in an African or Indian Ganja-plantation you will know all about this “plant-high’. In nature even plants grown for hemp can increase THC levels if they become stressed by the sun. THC is the plant’s natural ‘sunscreen so when exposed to hot sunlight, THC levels increase to protect the plant.

This means that the current THC limits permitted in ‘hemp plants’ are grossly underestimated and frankly a joke. At these levels we might never get any hemp industry started in Africa. The ultra-violet rays from the African sun are far too high for our farmers to operate within the proposed legal agenda. [5] 

People use Cannabis to feel better, to eat better, to sleep better, to be pain free, to relax and to be less stressed. These are all genuine medical conditions which we know Cannabis can cure. 

On a spiritual level people also use Cannabis to become the type of person they feel they really want to become, because for the majority of people, Cannabis can make them feel the way they want and need to feel. 

The amazing thing is that the acid version of THC has the exact same healing properties, but without the high

The proof of this fact is the hard-to-believe healing people are achieving just by juicing the raw Cannabis plant. People are healing themselves from various cancers just by juicing the raw plant. 

This is possibly the most preferred method of consuming Cannabis today, for people who don’t smoke or don’t want ‘the high’. [6]

It is now well established in the medical journals that both CBDA and THCA have been tested and found to more potent than CBD and THC. In one nausea study CBDA was found to be 1000 times more potent than CBD. And THCA was found to be 25 times more potent than THC in nausea studies.

“As with acute nausea, both CBD and CBDA reduce anticipatory nausea in this pre-clinical model by a 5-Ht receptor mechanism of action, with CBDA about 1000 times more potent than CBD. Neither CBD nor CBDA interfered with motor activity. Given that these compounds are non-psychoactive, future clinical trials with human patients are gravely needed as there are currently no specific treatments for anticipatory nausea in humans.” [46]

In Issue 170 and Volume 3 of the British Journal of Pharmacology published in October 2013, the authors evaluate the anti-nausea effects of THCA and discovered that the acid version of THC is more potent than the cannabinoid itself. 

“Therefore, THCA appears a more potent anti-nausea treatment than THC, even though it is not psychoactive. Additionally, it is unlikely that the anti-nausea effects of THCA in our models could be due to the metabolism of THCA into THC, given that the equivalent dose of THC is ineffective. Furthermore, when plasma samples were analyzed, no detectable levels of THC were present, only THCA. This evidence discounts the possibility that the effects were due to conversion of THCA to THC.” [47,48]  

SECRET NO 2 ~ ONLY THC BINDS TO THE ECS RECEPTORS

As a young herbalist my Rastafari teachers used to refer to the ECS as “The THC Receptors” and their explanation was because ONLY THC actually binds to these ‘Ganja receptors in the brain”. I always wondered how my Masters from the 1980’s had come by such knowledge since I could never find much information in books and encyclopedias in those days.

One of the best research papers I have read on the actual structure of the ECS receptors is written in a paper titled “The Crystal Anatomy of the Human CB1 Receptors.” You can tell whether a scientific paper might be enjoyable or not, and you can tell from the title!

The Chinese students speak about “Exceptionally deep binding pockets that appear complicated and expansive compared to other lipid (fat) binding receptors.” They state that these receptors “have larger surface areas and numerous sub-pockets and different networks to other areas of the receptors.” 

So you can tell from this in-depth paper that the THC receptors are no ordinary receptors. Only THC from the Cannabis plant has the necessary deep-binding affinity for these unique receptors. [7]

SECRET NO 3 ~ CANNABIS CONTROLS THE ENDOCRINE SYSTEM

This is one of the greatest secrets of how this medicine works so effectively. Hormonal imbalances are very often the root-cause of so many diseases including the so-called ‘auto-immune’ diseases. And so often these hormonal imbalances go by unnoticed, untested and ultimately untreated.

Cannabis and the ECS controls the activities of our Hormone System

When hormones are unbalanced, cells are unable to function properly and can even affect how our genes and DNA is expressed. 

In my book I state that Cannabis is the "Plant Whisperer" of human DNA, because this ongoing transmission to our DNA through the control of Cannabis over our hormonal system is proving to be the ultimate antioxidant to protect our cells in order to achieve healthy cell production and development throughout our lives.  

I am convinced that this is the biological reason why Cannabis has healed every type of cancer that it has been tested against. 

Cannabis can offer us protection against all types of cancers, neurological conditions, and brain damage. [8, 9]

Hormone disruption can lead to so many medical conditions for example: pain, inflammation, insomnia, cancers, diabetes, thyroid conditions, obesity, anorexia, hypertension, Fybromyalgia, headaches, neurological conditions like epilepsy and Altzheimer's Disease and dementia. Parkinson’s disease, autoimmune diseases, conditions of the nervous system like neuropathy (small and large fiber), cholesterol, muscular diseases, liver disease, vascular disease, heart disease, kidney and renal tract disease, gut diseases, osteoporosis, depression, stress, anxiety, and the big one - vitamin D deficiency.

This medical truth, that the ECS controls the Endocrine system, has helped us to understand some of the mechanisms by which Cannabis is able to heal so effectively.

This is why Cannabis can help us to enjoy a good night of sleep, and how this amazing plant can help us to overcome many of life’s stresses that we all endure today. [10]

Stress and sleep deprivation are two of the biggest causes of all medical conditions, so you can see how a lot of diseases start off due to a hormonal problem. Scientists are now pursuing studies involving the role of Cannabinoids in hormone release in the treatment of fertility problems, mood and anxiety disorders, and metabolic processes such as thyroid function, as well as symptoms of autism. 

All of these processes are controlled by our hormone system which is controlled by our EC system, and which needs plant-derived cannabinoids from the Cannabis plant for supplementation. [11]

Knowing that we have a Cannabis-dependent system within each one of us that is responsible for the well-being of all our physiological systems surely makes us realize that Cannabis has the most profound effect on the human body, mind and spirit.

SECRET NO 4 ~ RECEPTOR EXPRESSION

The entire Human Receptor System is as unique as your fingerprint and the iris of your eyes. This means that receptor expression is a subjective experience and unique to each individual, so there are about 8 billion Endocannabinoid systems on the planet today. 

This is one of the main reasons why Cannabis medicine will never be a ‘one size fits all’ treatment because one cannot standardize individual treatment plans for 8 billion unique systems that need Cannabis to survive.

There is only one place in the body where there are no ECS receptors....

One of the most remarkable observations about receptor expression is that there are no ECS receptors on the cardiac and respiratory cells of the human brainstem. 

This is one of the reasons for the high safety margin of Cannabis medicine and the very reason why no one has ever died or overdosed from this natural whole herbal plant medicine from stopping to breathe or from their heart stopping, and never will.

Some people over-express ECS receptors and may be more sensitive to THC and others under-express and are less sensitive and need higher doses

Receptor Expression also highlights the protective role of the ECS...

There are research results in liver cancer studies that show that patients with liver damage had a higher expression of cannabinoid receptors in their liver tissues than healthier liver patients. 

A higher expression of EC receptors in a certain region indicates where the healing is needed...

I have this little test I do whenever the opportunity arises, which is often! Around a table I will randomly ask if anyone has a headache or any kind of pain or nervous issues.

I then offer the oil and ask the person to gently dab a little oil on the exact location of their pain or shakes so either on their forehead, their temples or the back of their neck are common application spots and people with spasms and shakes will apply a few drops on the hands and arms

After seven minutes most people have found relief and people with the shakes stop shaking!

At any site of injury in the body when neural or non-neural cells in the tissues are injured and damaged, there will be a localized up-regulation in the expression of our cannabinoid receptors in that exact location. 

So, for example, if there is a pinched nerve in the neck, the body will naturally increase the amount of cannabinoid receptors in the precise location where the pain is felt. The ECS requires cannabinoids from the Cannabis plant to effect healing. 

This means that local application of Cannabis oil is highly effective for pain relief, and many other medical conditions.[12]

Wherever there is illness or injury in the body, the cannabinoid receptors will increase their expression in that exact location, as they wait to be activated by cannabinoids to effect healing, not only systemically but also locally. 

This is why sick people need Cannabis to supplement their EC System and ensure healing, and healthy people need the plant to prevent illness [13]

In order for receptors to function they need either to be activated or not be activated. Some cannabinoids act as activators of receptors and others as inhibitors, while others act as indirect or partial agonists and modulators of the activities of other cannabinoids. 

We must accept that the ECS is a delicate biological system that works completely differently from any other system we have known or might know

Scientists struggle to understand how Cannabis heals because a big part of receptor expression involves the fact that the plant and the biological ECS has dual healing purpose, which means it can do anything as is required. It’s a bold claim but the evidence speaks volumes. 

This is why Cannabis appears to offer healing for almost any condition, and delivers positive results in the shortest space of time with minimal side-effects. This is not a magical illusion this is real live healing that the plant has been offering to human beings for thousands of years. [14]

What does ‘Duality of Cannabis healing’ mean?

One of the mysteries of Cannabis medicine is the hypothesis of dual-healing-purpose. This two-fold healing ability of Cannabis and specifically THC ensures, for example, that Cannabis can both increase and decrease blood pressure in different individuals.

It can induce clotting of the blood when needed, and it can also thin blood out. It can both stimulate and suppress the appetite. It can both block and unblock receptors. Cannabis can act as both an agonist as well as an antagonist of any cannabinoid receptor and certain others as well. These are things that no other medicine can do. Another good example of the duality of Cannabis medicine is how the Cannabinoid CBD is able to regulate the psychedelic effects of the activity of THC. [15]

Another amazing example of receptor expression is how Cannabis cures Glaucoma…


In 1978 Peter Tosh in his album titled Bush Doctor Peter Tosh declared that “It’s the only cure for glaucoma”, referring to Cannabis. Almost forty five years later people are only now starting to realize that this is actually the truth. Today we know that there are more cannabinoid receptors in the eyeball than in the rest of the brain, including the visual cortex in the brainstem. So, a patient with glaucoma will have a raised expression of cannabinoid receptors in the eyeball compared to the visual cortex of the brain. 

This increased expression of EC receptors in the eyeball proves that healing takes place locally, within the retina, instead of within the visual cortex of the brain...

There is a very interesting study published in the British Journal of Ophthalmology in 2004. The study found that, unlike other conditions treated by Cannabis, glaucoma does not rely on the effect of the cannanbinoids on the central nervous system. 

This is due to the over-abundance of cannabinoid receptors in the retina of the eye. Again, this suggests that healing is taking place within the actual eye and the increase in cannabinoid receptor expression in the retina is proof of this. 

The true medicinal worth of Cannabis in treating glaucoma and other eye conditions lies in the fact that the efficiency of Cannabis is localized.

This also confirms that relief for glaucoma can also be gained from topical applications of Cannabis medicine, for example eye drops. Cannabinoids increase the blood flow to the eye and deliver cannabinoids directly to the eye for repair. [16]

Here is a quotation from Doctor Sunita Radhakrishnan, MD who specializes in the medical and surgical treatment of glaucoma at the Glaucoma Centre of San Francisco. She is also Research Director at the Glaucoma Research and Education Group in San Francisco. 

 

“The fact of the matter: The only way to treat glaucoma is to lower IOP, and an effective way to lower IOP — according to literally hundreds of anecdotal patient testimonies and volumes of research studies dating back 45 years — is to consume cannabis via smoking, vaporizing, eating, or sublingually as a tincture. For some patients who have failed lots of treatments, [Cannabis] is the only thing that keeps them from going blind.”  [17]

In my opinion, identifying receptor expression is the future of curative and preventive medicine, because simply put, if a healer or doctor could identify Cannabinoid receptor expression then they would immediately know where to target the healing, instead of simply treating symptoms. [18]

SECRET NO 5 ~ RETROGRADE TRANSMISSION

Plant derived cannabinoids as well as our own naturally produced endocannabinoids are the most numerous of all neurotransmitters. All other neurotransmitters move from the post-synaptic cell forward to the pre-synaptic cell (control is at the post-synaptic cell) but cannabinoids and endocannabinoids work in reverse, moving from the pre-synaptic cell backwards to the post-synaptic cell (control is at the pre-synaptic cell). 

It is interesting to note that THC & THCV can move in both directions! This means that Cannabis and the ECS can literally control what happens ‘next’ at cellular level and this is why doctors are baffled at how quickly and effectively Cannabis can heal virtually any condition!


When any cell is under attack, the ECS receptors immediately kick into action, but it communicates its messages in a unique way because it essentially works in reverse. This is referred to as ‘retrograde transmission’ where the neurotransmitters attach themselves to the receptors on the pre-synaptic neuron, and move backwards to the post-synaptic neuron. 

No other receptor or neurotransmitter can do this. All other neurotransmitters in the human body (except Nitric oxide) move forward, from the post to the pre-synaptic neurons, and not the other way round. [19]

The importance of this is that cannabinoids can act on pre-synaptic cells, and they can also control what happens next when these cells are activated. 

This is another explanation for the miraculous healing abilities of humanity’s healing herb. Because of this unique feature, the ECS moves backwards, but is actually in the future, and can affect the future at cellular level. This is in my opinion what makes Cannabis the future of modern medicine. [20]

SECRET NO 6 ~ THE ENTOURAGE EFFECT

The reason why the actual plant cures more effectively than synthetics is that ‘The Entourage Effect’ is present in the whole herbal plant. This is the botanical understanding that all of the plant’s chemical components must be present in the recipe. 

All of the different Cannabinoids and terpene profiles, terpenoids and flavinoids together are involved in the healing process, and they all have to work together to achieve the magical healing properties we have come to know and respect, from whole herbal Cannabis.

We must all realize that CBD and THC are only a part of the equation. The concept of the Entourage Effect comes from the Hebrew University in Israel from the laboratory of Professor Raphael Mechoulam. It describes how all of the chemical compounds of the plant must work together in harmony to create the total of all the plant parts, which then combine to create the magical and mystical healing powers of the human companion plant.  [21]

The Entourage Effect is the natural combination of hundreds of known cannabinoids, as well as hundreds of other chemical components which together produce the specific natural effects of whole herbal Cannabis. There are even terpenes and terpenoids of which over 200 have already been identified. They also mimic the actions of cannabinoids, and also have their own special healing powers, so no-one really knows the true number of chemical components within the Cannabis plant.

SECRET NO 7 ~ THE SETTING OF INTENTION

Cannabis works on the principle of intention, meaning that we are to respect the plant by stating our purpose for consuming Cannabis and what type of healing we are looking for each time. 

This has to do with the patient’s mindset before using Cannabis and can result in incredibly powerful healings as though healing really did come from the mind.

My Rastafari teachers have instilled huge respect upon this plant and every time that we consume any part of our sacred herb we set intention by way of prayer and the ritual in which we clean the herb and separate the seeds from the flowers. And in this way we pay respect to the Creator for providing us with such a healing plant of renown that earns the right to be loved, respected and praised. 

In the setting of intention before consumption we each develop our own unique and special relationship with the human companion plant.

In 2021 I received the following review that showed me that the reader completely understood the concept of setting intentions.


 SECRET NO 8 ~ THE CHAKRA SYSTEM

The Endocrine System is the main support system for the Chakra system and we now know that the ECS controls the endocrine system and therefore the chakra system as well. Chakras are not physical organs in our body but rather universal elements of spirituality. It is no co-incidence that each of the seven main internal chakras is naturally aligned to a ductless Endocrine gland.


By stimulating and balancing the ECS and endocrine system we can open up our spiritual chakras, but, ALL 7 chakras must be open at the same time for healing and meditation to take place. In my opinion Cannabis is able to control all of our bodily processes, through its interaction with all of our other physiological systems including the chakra system. [22]

Why is the chakra system so important?

By consuming Cannabis we create expanded space for energy to flow freely in the chakras as well as in the physical body; this clears blockages and effects healing. The balancing and unblocking of chakras has been the ethos of Traditional Chinese Medicine (TCM) for thousands of years. Even under Emperor Shen Neng (2737 BC) Cannabis was first on the list of Chinese medicines amongst other conditions to treat gout, malaria, rheumatism and forgetfulness.

This is why I believe that Eastern herbalists have been healing with Cannabis for millennia, because they’ve always known that Cannabis can help us to open and unblock our chakras and this is a prerequisite of healing. 

Herbal medicine often works better than man-made drugs, because all plants work with our chakra system, but only Cannabis can open our chakras up to vibrate to the frequency of 432 Hz which the frequency of love, harmony, the earth and the human body, and of course Cannabis itself. This is the frequency of balance, where healing, higher thinking, joy and wisdom can take place.

Most people do not even know that we have a chakra system, let alone where it is situated or what seals to open or what colors to use in order to activate each chakra, in order to heal ourselves. By learning to work with our chakras, we can enable ourselves to access certain states of ecstasy, increased use of our brains, slowing down of the ageing process and even experiencing ever-lasting life as some believe. 

You could say that our chakras are really just body parts we were never taught we have. For a lot people the ECS is also just another body part we were never told about.

SECRET NO 9 ~ AUTOPHAGY

Cannabis kills cancer cells through more than one mechanism namely anti-angiogenesis, apoptosis and autophagy. There are a few processes involved, starting with the boosting of the ECS, the treating of inflammation and the strengthening of the immune system.

Autophagy (pronounced or-tof-o-gee)  is a process involving cellular destruction of unnecessary or dysfunctional cellular components and mutant cells. This is how Cannabis helps us to get rid of damaged cells like cancerous cells for instance. 

Damaged organelles, cell membranes and proteins are broken down and excreted, but there is no damage at all to healthy cells, unlike most cancer-fighting drugs which kill off healthy and damaged cells. Both CBD and THC are able to increase autophagy and thereby decrease tumor growth and progression. [23-25]

Through the process of autophagy the body can suppress the growth of tumors by preventing damaged components of the cells to accumulate. These mutant cancerous cells are dreadful and deadly because they have lost their ability to undergo another process known as apoptosis. 

This is programmed cell death, and this is the reason that they don’t simply die and carry on multiplying. Cannabis induces apoptosis and autophagy in cancer cells, through the healing powers of the cannabinoids, terpenes, flavinoids, antioxidants and polyphenols contained within the plant.


Cannabis is the only known botanical that is capable of inducing autophagy

Cannabis induces the biological process of autophagy through the mechanism that is now famously known as ‘the munchies’. The only other real way to induce autophagy is to teach the patient how to fast by withholding food and forcing the body into a state of hunger. Cannabis does this quite successfully with the minimum of effort for the patient.

Autophagy is not only useful for preventing cancer formation but also for a number of other health benefits for example resetting of the nervous and immune systems. There is no doubt that autophagy is a therapeutic target to reverse many diseases including so called ‘auto-immune’ diseases as well as age-related degenerative conditions like osteoporosis and arthritis and even dementia. 

Restricting calories and exercising intermittent or alternate-day fasting has so many benefits for achieving great health.

One of the reasons why Cannabis is able to induce autophagy is because of the presence of a terpene known as D-limonene and together with Humulene, another powerful Cannabis terpene, these form a major part of the cancer-defense system of Cannabis because both together with the cannabinoids are able to trigger the production of Reactive Oxygen Species (ROS) and this is what causes autophagy and apoptosis to occur. [26-36]

The failure of the process of autophagy is the main reason for on-going cell damage and cancer, and this is also what speeds up the aging process. It seems obvious that we need to boost our systems with Cannabis in order to maintain good health and longevity into our golden years. [37]

We know that Cannabis can cure cancer, and it is now a well-known scientific fact that Cannabis has effectively killed all the different types of cancer cells that science has tested to date. [38] There is now scientific proof that the EC system is involved in the cellular death of human proximal tubular (HK2) cells. [39]

These human kidney cells originate from the kidney cells of the HK2 gene on the 2nd chromosome, and these cells are required in the formation of tumors in most cancers and these cells cause renal tubule hypertrophy (enlargement of cells). 

Through the function of autophagy and apoptosis our ECS is able to cause these cells to commit cellular suicide. 

This is how Cannabis contributes to reducing hypertrophy throughout the body by providing the supplements that our ECS needs to perform its functions. Every single one of us needs a daily dose of Cannabis to sustain our health and the fact that we have Cannabis receptors in our brains is proof that we are literally wired to consume this plant. [40]   


Looking to the future…

Doctors ask me all the time how is it possible that they could have studied the human body for 7 years but never have heard about the ECS? 

For reasons that only the Babylon system will ever over-stand, this vital information does not form part of the curriculum served at medical schools. The people in charge of the medical system clearly do not acknowledge or concern themselves with the ECS and further they clearly do not believe that Cannabis has any medicinal properties and despite the mountains of evidence they keep on insisting that ‘more research is needed’.

In my opinion there is sufficient research, in fact Cannabis medicine is the most researched of all medicines since the 90’s. What needs to happen now is that Anandamide needs to be administered in human trials as this has unbelievably still never been done. Even Professor Mechoulum does not have an explanation as to why this is. 

We know that with old age comes the natural deterioration of cells, tissues, organs, memory and brain function. 

However, we also know that in Cannabis we have a plant confidante that can offer us new brain cells, bodily and hormonal balance, cellular suicide of mutant cancer cells, metabolic control, as well as pain relief, and can also guarantee us a good night’s sleep.

All of this makes Cannabis the perfect supplement to reverse age-related body and brain deterioration

We know that Cannabis helps us to increase our uptake of vitamin D, which is crucial to preventing conditions like Alzheimer’s and dementia, as well as cancer. We should realize that our lifestyles could quite literally be killing us. 

If you consider how our ancient relatives lived longer and less stressful lives, then we can agree that for the majority of people, their actual jobs are the number-one source of stress and illness. There are even serious studies suggesting that ‘sitting is the new smoking’, and these studies prove that sitting for too long, meaning up to six hours at a time continuously, can lead to early death. [41]

I must keep going back to the importance of sleep and it is my belief that human longevity is strongly associated with healthy sleep patterns, and we know now how Cannabis makes us sleep better. 

If you think about it, there isn’t really a single problem that lack of sleep does not make worse. The side-effects of missing out on sleep are irritability, cognitive impairment, a decrease in sense of accuracy, memory lapse or in some cases total loss of memory. 

Lack of sleep can also lead to decreased creativity, increased stress levels, headaches, aches and pains, increased heart rate and high blood pressure. Lack of sleep will take its toll on the immune system which could easily become suppressed. 

The well documented triumphs of Cannabis medicine are the reason why senior citizens are becoming the fastest growing segment of Cannabis consumers and eventually the secret will be out that Cannabis truly can offer humans longevity.

On a spiritual level Cannabis can help us to deal with our questions and fears about life, love, death, and transcending to the afterlife and beyond...

It is the psychoactive effects of THC that can induce feelings of elation and relaxation in certain people, whereas in others who have heavy hearts it can bring about feelings of paranoia and fear. 

Death is never easy, because we really don’t know much about it, but one thing is for certain, death is always going to be part of life. 

This is why it is so important to address our spiritual health while we live. It is the psychedelic properties of Cannabis, meaning THC and all of its analogues that can help us to achieve such enlightenment. 

THC can take us to levels of consciousness we are not able to reach without psychedelics,


Enlightenment and spiritual growth are what Cannabis can offer us by giving us all an increased feeling of positivity. This is exactly why so many people use Cannabis as their sacrament. 

Through the consciousness of the Cannabis plant we can expand our own consciousness to promote love and kindness in this world, which could quite possibly make consciousness the new currency of the universe.

In my work I have witnessed the divine feminine qualities of Cannabis, and I have seen how this plant can nurture humans and animals through her healing abilities. I have also witnessed the divine masculine qualities of the male Cannabis plant and you can read about a fascinating story in the last chapter of my book. 

Cannabis is a compassionate companion, and makes us feel better by offering intense healing, intuition and sensitivity that one would come to expect to receive from a human companion plant. [42-45]


CITATIONS FOR THE SECRETS OF THE HUMAN COMPANION PLANT

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[2] (Liu et al, February 2015) “The effect of chronic stress on anti-angiogenesis of sunitinib in colorectal cancer models.” Journal Phsychoneuroendocrinology Volume 52 pages 130 – 142. PMID: 25437118

[3] (Freya Kamel and Jane A Hoppin, May 2004) “Association of Pesticide Exposure with Neurologic Dysfunction and Disease”. Journal Environmental Health Perspective Volume 112 Issue 9 pages 950-958 PMCID: PMC1247187 PMID 15198914

[4] (Zuardi et al, 2012) For so many people, Cannabis is able to take their pain away, making them feel better within minutes, with relief that lasts for hours. It is a combination of the many benefits of Cannabis that contributes to the distraction from our physical and emotional aches and pains.

[5] (Atakan Z, 6 December 2012) “Cannabis, a complete plant: Different compounds and different effects on individuals.” Journal Therapeutic Advances in Psychopharmacology Volume 2 Issue 6 pages 241-254. PMCID: PMC3736954 PMID: 23983983 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/

[6] (EM Rock and LA Parker, June 2013) “Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behaviour) in rats”. British Journal of Pharmacology Volume 169 Issue 3 pages 685-92. PMID: 23488964 PMCID: PMC3682714 DOI: 10.1111/bph.12162 https://pubmed.ncbi.nlm.nih.gov/23488964/

[7] (J.Coffey, JingjingWang, MengWu, VsevolodKatritch, Zhi-JieLiu, 2019) “Crystal Structure of the Human Cannabinoid Receptor CB2” Science Direct Volume 176 Issue 3 page750-762 24 January 2019

[8] (hemphealer.com, 2012) “Hemp repairs DNA” The Inspired Observer 14 April 2012

[9] (Jan Komorowski et al 2007) “The Role of the Endocannabinoid System in the Regulation of Endocrine Function and in the Control of Energy Balance in humans”. Journal High Med Dosw. Volume 61 pages 99-105 PMID: 17369778

[10] (Kuem Sun Han et al December 2012) “Stress and Sleep Disorder”. Experimental Neurobiology Journal Volume 21 Issue 4 pages 141-150 PMCID PMC 3538178 PMID 23319874

[11] (Jan Komorowski et al 2007) “The Role of the Endocannabinoid System in the Regulation of Endocrine Function and in the Control of Energy Balance in Humans”. Postepy High Med Journal Dosw Volume 61 pages 99-105

[12] (A Parfieniuk and Robert Flisiak (2008) “The Role of Cannabinoids in chronic liver disease” World Journal of Gastroenterology PMCID: PMC2761570 PMID: 1895799 Volume 14 Issue 40 Pages 6109-6114 28 October 2008

[13] (Lydia K Miller et al September 2011) “The Highs and Lows of Cannabinoid Receptor Expression in Disease: Mechanisms and their Therapeutic Implications” Pharmacol Rev Journal Volume 63 Issue 3 pages 461-70. PMID 21752875 PMCID: PMC3141881

[14] (Pal Pacher and George Kunos, May 2013) “Modulating the Endocannabinoid System in Human Health and Disease: successes and failures”. The FEBS Journal Volume 280 Issue 9 Pages 1918-1943. PMCID: PMC368 NIHMSID: NIHMS5460242 PMID: 23551849

[15] (Wilson RI, 2001) “Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses” Pub Med 29 March 2001

[16] (Tomida, 2004) “Cannabis and glaucoma”. British Journal of Opthalmology Volume 88 Issue 5, 2004

[17] (Rabinski, 2016) “Can Cannabis Treat Glaucoma?” Posted www.massroots.com 16 February 2016

[18] (FabianaPiscitelli, 2015) “Endocannabinoidomics: “Omics” Approaches Applied to Endocannabinoids and Endocannabinoid-Like Mediators” The Endocannabinoidome Journal pages 137-152, 2015

[19] (Christie MJ, Vaughan CW, Pertwee RG, 2005) “Retrograde Signallling by Endocannabinoids”. Pertwee RG, Handbook of Experimental Pharmacology Volume 168, Springer, Berlin, Heidelberg

[20] (Masanobu Kano, July 2014) “Control of Synaptic Function by Endocannabinoid mediated Retrograde Signalling”. Proceedings of the Japan Academy Journal Ser B Phys Biological Science Journal. Volume 90 Issue 7 Pages 235-250. PMCID PMC4237895 PMID 25169670

[21] ((MarzodRaphaelMechoulama, 1998)) “An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity”. European Journal of Pharmacology Volume 353 Issue 1 pages 23-31 17 July 1998

[22] (Pal Pacher et al February 2008) “The Endocannabinoid System as an emerging target of Pharmacological therapy” Pharmacol Rev Journal Volume 58 Issue 3 pages 389-462 PMCID PMC2241751  NIHMSID: NIHMS38123 PMID 16968947

[23] (Tomko et al, 21 July 2020) “Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonids Present in Cannabis.” Journal Cancers Volume 12 Issue 7 page 1985 PMCID: PMC7409346 PMID: 32708138

[24]  Armstrong J.L., Hill D.S., McKee C.S., Hernandez-Tiedra S., Lorente M., Lopez-Valero I., Eleni Anagnostou M., Babatunde F., Corazzari M., Redfern C.P.F., et al. Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death. J. Investig. Dermatol. 2015;135:1629–1637. doi: 10.1038/jid.2015.45. 

[25] Glodde N., Jakobs M., Bald T., Tüting T., Gaffal E. Differential role of cannabinoids in the pathogenesis of skin cancer. Life Sci. 2015;138:35–40. doi: 10.1016/j.lfs.2015.04.003. 

[26] Hajizadeh M., Maleki H., Barani M., Fahmidehkar M., Mahmoodi M., Torkzadeh-Mahani M. In vitro cytotoxicity assay of d-limonene niosomes: An efficient nano-carrier for enhancing solubility of plant-extracted agents. Res. Pharm. Sci. 2019;14:448–458. doi: 10.4103/1735-5362.268206. 

[27] Hafidh R.R., Hussein S.Z., MalAllah M.Q., Abdulamir A.S., Abu Bakar F. A high-throughput quantitative expression analysis of cancer-related genes in human HepG2 cells in response to limonene, a potential anticancer agent. Curr. Cancer Drug Targets. 2018;18:807–815. doi: 10.2174/1568009617666171114144236. 

[28] Zhang X.-Z., Wang L., Liu D.-W., Tang G.-Y., Zhang H.-Y. Synergistic inhibitory effect of berberine and d-limonene on human gastric carcinoma cell line MGC803. J. Med. Food. 2014;17:955–962. doi: 10.1089/jmf.2013.2967. 

[29] Bishayee A., Rabi T. d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis. J. Carcinog. 2009;8:9. doi: 10.4103/1477-3163.51368. 

[30] Berliocchi L., Chiappini C., Adornetto A., Gentile D., Cerri S., Russo R., Bagetta G., Corasaniti M.T. Early LC3 lipidation induced by d-limonene does not rely on mTOR inhibition, ERK activation and ROS production and it is associated with reduced clonogenic capacity of SH-SY5Y neuroblastoma cells. Phytomedicine. 2018;40:98–105. doi: 10.1016/j.phymed.2018.01.005. 

[31] Russo R., Cassiano M.G.V., Ciociaro A., Adornetto A., Varano G.P., Chiappini C., Berliocchi L., Tassorelli C., Bagetta G., Corasaniti M.T. Role of d-limonene in autophagy induced by bergamot essential oil in SH-SY5Y neuroblastoma cells. PLoS ONE. 2014;9:e113682. doi: 10.1371/journal.pone.0113682. 

[32] Yu X., Lin H., Wang Y., Lv W., Zhang S., Qian Y., Deng X., Feng N., Yu H., Qian B. d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer. Onco Targets Ther. 2018;11:1833–1847. doi: 10.2147/OTT.S155716. 

[33] Haag J.D., Lindstrom M.J., Gould M.N. Limonene-induced regression of mammary carcinomas. Cancer Res. 1992;52:4021–4026. 

[34] Gould M.N., Moore C.J., Zhang R., Wang B., Kennan W.S., Haag J.D. Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras. Cancer Res. 1994;54:3540–3543. 

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[36] Nakaizumi A., Baba M., Uehara H., Iishi H., Tatsuta M. d-Limonene inhibits N-nitrosobis(2-oxopropyl)amine induced hamster pancreatic carcinogenesis. Cancer Lett. 1997;117:99–103. doi: 10.1016/S0304-3835(97)00207-3. 

[37] Manuele M.G., Barreiro Arcos M.L., Davicino R., Ferraro G., Cremaschi G., Anesini C. Limonene exerts antiproliferative effects and increases nitric oxide levels on a lymphoma cell line by dual mechanism of the ERK pathway: Relationship with oxidative stress. Cancer Investig. 2009;28:135–145. doi: 10.3109/07357900903179583. 

[38] Cannabis is the Human Companion Plant Chapter 3 page 24 and 18

[39] (Weeks, 2018) “Standard cancer treatment must be adapted to the type and location of tumor,whereas Cannabis is an equal opportunity killer. Cannabis can kill all types of cancer cells” www.rxleaf.com 27 November 2018 

[40] (Velasco PhD et al 2016) “Anti-cancer mechanisms of cannabinoids”. Current Oncology Journal 16 March 2016 Volume 23 (Suppl 2) pages 523-532 PMCID: PMC 4791144 PMID: 27022311

[41] (Dr Edward R Laskowski MD, Mayo Clinic, 2018) “What are the risks of sitting too much?” 8 May 2018

[42] (Jenkin KA et al, 2010) Physiology and Biochemistry Journal Volume 26 Issue 6 (879-86) Research Gate January 2010

[43] (hemphealer.com, 2012) “Hemp repairs DNA” The Inspired Observer 14 April 2012

[44] (Jan Komorowski et al 2007) “The Role of the Endocannabinoid System in the Regulation of Endocrine Function and in the Control of Energy Balance in humans”. Journal High Med Dosw. Volume 61 pages 99-105 PMID: 17369778

[45] (J Garcia-Leme and Sandra P Farsky 1993) “Hormonal Control of Inflammatory Responses” Journal Mediators Inflammation Volume 2 Issue 3, PMC 2365405 PMID: 18475521

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